Experimental Biology and Medicine
Experimental Biology and Medicine (EBM) was founded in 1903 and is the flagship journal for the Society for Experimental Biology and Medicine (SEBM) (www.sebm.org). Membership in SEBM is open to all researchers in the biological sciences, and even offers free student membership. SEBM members receive free page charges (https://www.sebm.org/join-sebm).
EBM provides both research and review articles as well as meeting symposia and brief communications. Articles represent cutting edge research at the overlapping junctions of the biological, physical and engineering sciences that impact on the health and welfare of the world's population.
Experimental Biology and Medicine (EBM) is a global, peer-reviewed journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. EBM provides both research and review articles as well as meeting symposia and brief communications. Articles in EBM represent cutting edge research at the overlapping junctions of the biological, physical and engineering sciences that impact upon the health and welfare of the world's population.
Topics covered in EBM include: Anatomy/Pathology; Biochemistry and Molecular Biology; Bioimaging; Biomedical Engineering; Bionanoscience; Cell and Developmental Biology; Clinical Trials; Endocrinology and Nutrition; Environmental Health/Biomarkers/Precision Medicine; Genomics, Proteomics, and Bioinformatics; Immunology/Microbiology/Virology; Mechanisms of Aging; Neuroscience; Pharmacology and Toxicology; Physiology; Stem Cell Biology; Structural Biology; Systems Biology and Microphysiological Systems; and Translational Research.
| Steven R. Goodman, PhD | University of Tennessee Health Science Center, Memphis, TN, USA |
| Gordon Awandare, PhD | University of Ghana, Africa |
| Shaw-Jeng Tsai, PhD | National Cheng-Kung University Medical College, Taiwan |
| Nicola Conran, PhD | University of Campinas, Brazil |
| Farzin Farzaneh, PhD | King's College London, UK |
| Y James Kang, DVM, PhD | Regenerative Medicine Research Centre, Sichuan University West China Hospital, Chengdu, China |
| Aaron Ciechanover, MD/PhD | The Technion Institute, Israel |
| Russell Hulse, PhD | The University of Texas at Dallas, USA |
| Ian S. Zagon, PhD | Pennsylvania State University, USA |
| William Allen Banks, MD | VA Puget Sound Health Care System, USA |
| Lynda Bonewald, PhD | University of Kansas, Missouri, USA |
| Beverley Greenwood-Van Meerveld, PhD | The University of Oklahoma, College of Medicine, USA |
| Alexander V. Ljubimov, PhD, DSc, | Cedars-Sinai Med Ctr, Los Angeles, USA |
| Patricia J. McLaughlin, DEd | Penn State University College of Medicine, USA |
| Artur Pasternak, MD, PhD | Jagiellonian University Medical College, Poland |
| Douglas F. Paulsen, PhD | Morehouse School of Medicine, USA |
| Ann M. Schreihofer, PhD | University of North Texas HSC, USA |
| Theodore Slotkin, PhD | Duke University Medical Center, USA |
| R. Alberto Travagli, PhD | Penn State Hershey Medical Center, USA |
| Muriel W. Lambert, PhD | Rutgers New Jersey Medical School, USA |
| Brian Adams, PhD | The Brain Institute of America, USA |
| Robert M. Brosh Jr., PhD | National Institutes of Health, USA |
| Shyamal D. Desai, PhD | Louisiana State University Health Sciences Center, USA |
| James P. O’Connor, PhD | Rutgers New Jersey Medical School, USA |
| Aleksander F. Sikorski, PhD | University of Wroclaw, Poland |
| Howard J. Worman, MD | Columbia University, USA |
| Shuliang Jiao, PhD | Florida International University, USA |
| Ignacy Gryczynski, PhD | University of North Texas Health Science Center, USA |
| Zygmunt (Karol) Gryczynski, PhD | University of North Texas Health Science Center, USA |
| Hong Liu, PhD | University of Oklahoma, USA |
| Kate Luby-Phelphs, PhD | University of Texas Southwestern Medical Center, USA |
| Qingming Luo, PhD | Huazhong University of Science & Technology, Wuhan, China |
| Xinmai Yang, PhD | The University of Kansas, USA |
| Xincheng Yao, PhD | University of Illinois at Chicago, USA |
| Baohong Yuan, PhD | University of Texas at Arlington, USA |
| Weizhao Zhao, PhD | University of Miami, Florida, USA |
| Horst A. von Recum, PhD | Case Western Reserve University, USA |
| Eun Ji Chung, PhD | University of Southern California, USA |
| Stuart L. Cooper, PhD | The Ohio State University, USA |
| F. Kurtis Kasper, PhD | University of Texas HSC, USA |
| Angela Pannier, PhD | University of Nebraska, USA |
| Adam Perriman, PhD | University of Bristol, UK |
| Juan Andres Melendez, PhD | SUNY – Polytechnic Institute, USA |
| Nathaniel C. Cady | SUNY Polytechnic Institute, USA |
| Hassan A. N. El-Fawal, PhD | American University in Cairo, Egypt |
| Mark Kester, Ph.D. | University of Virginia, USA |
| Jonathan Lovell, PhD | State University of New York at Buffalo, USA |
| Gabriel A. Silva,PhD | University of California, San Diego, USA |
| Ya-Ping Sun, PhD | Clemson University, USA |
| M. Silvina Tomassone, PhD | Rutgers University, USA |
| Jie Zheng, PhD | The University of Texas at Dallas, USA |
| Siyang Zheng Ph.D. | Carnegie Mellon University, USA |
| Warren E. Zimmer, PhD | Texas A&M University, USA |
| David A. Dean, PhD | University of Rochester, USA |
| Leszek Kotula, MD | SUNY Upstate Medical University, USA |
| William E. Miller, PhD | University of Cincinnati College of Medicine, USA |
| Harold Ivan Saavedra PhD | Ponce Health Sciences University, Puerto Rico |
| Yigang Wang, M.D., Ph.D., F.A.H.A. | University of Cincinnati College of Medicine, USA |
| Susanne Wells, PhD | University of Cincinnati College of Medicine, USA |
| Ari M. VanderWaide MD, MPH, Mbioeth, FACP | West Cancer Center, USA |
| Yehoshua C. Levine, MD | University of Tennessee HSC, USA |
| Giuseppe Pizzorno, PharmD | University of Tennessee HSC, USA |
| Daniel Vaena, MD | University of Tennessee HSC, USA |
| Nancy Turner, PhD | Michigan State University, USA |
| Clint Allred, PhD | University of North Carolina at Greensboro, USA |
| Samuel Dagogo-Jack, MD | University of Tennessee, USA |
| Mykola D. Khalangot, MD, PhD, ScD | Shupyk Natl Med Academy of Postgraduate Education, Ukraine |
| Ramesh Narayan, PhD, MBA | University of Tennessee HSC, USA |
| B.L. Gregoire Nyomba, MD, PhD | University of Manitoba, Canada |
| Gabrielle Page-Wilson, MD | Columbia University, USA |
| Eugene Sobngwi, MD, MPh, PhD | University of Yaounde, Cameroon |
| Weiqun (George) Wang, PhD | Kansas State University, USA |
| Malcolm Watford | Rutgers University, USA |
| William Slikker, Jr., PhD | US Food and Drug Administration, USA |
| Ritchie Feuers, PhD | US Food and Drug Administration, USA |
| Gary Steven Friedman, MD | Pfizer, Inc., USA |
| Donald J. Johann Jr., MD | University of Arkansas for Medical Sciences, USA |
| Donald R. Mattison, MD | Risk Sciences International/University of Ottawa, Canada |
| Donna L. Mendrick, PhD | US Food and Drug Administration, USA |
| John-Michael Sauer, PhD | Critical Path Institute, USA |
| Cheng Wang, PhD | US Food and Drug Administration, USA |
| Paul Brent Watkins, MD | University of North Carolina, USA |
| Sulev Koks, MD, PhD | The Perron Institute for Neurological and Translational Science, Australia |
| Robert W. Williams, PhD | University of Tennessee HSC, USA |
| Mark Geraci, MD | University of Pittsburgh, USA |
| Stephen J. Glatt, PhD | SUNY Upstate Medical University, USA |
| James Lyons-Weiler, PhD | The Institute for Pure and Applied Knowledge, USA |
| Momar Ndao, DVM, PhD | Montreal General Hospital, Canada |
| Paul Keith Potter, PhD | Oxford Brookes University, UK |
| John Peter Quinn, PhD | The University of Liverpool, UK |
| Heinrich Roder, PhD | Fox Chase Cancer Center, USA |
| Giovanni Stracquadanio, PhD | University of Edinburgh, UK |
| Linda Barber, PhD | King's College London, UK |
| Andrea Doria, MD | University of Padova, Italy |
| Farzin Farzaneh, PhD | King's College London, UK |
| Kam Man Hui, PhD | National Cancer Centre Singapore, Singapore |
| Jacques-Olivier Pers, PhD | CHRU Morvan, France |
| Francois Villinger, PhD | University of Louisiana at Lafayette, USA |
| Shigemi Matsuyama, PhD, DVM | Case Western Reserve University, USA |
| Ricki Jean Colman, PhD | University of Wisconsin, Madison, USA |
| Ao-Lin Allen Hsu,, PhD | University of Michigan Medical School, USA |
| Akhiro Ikeda, PhD, DVM | University of Wisconsin-Madison, USA |
| Masaru Miyagi,, PhD | Case Western Reserve University, USA |
| Vincint M. Monnier, MD | Case Western Reserve University, USA |
| Kenneth Raj, PhD | Public Health England (PHE), UK |
| Shinichi Somaya, PhD | University of Florida, USA |
| Michael Lehman, PhD | Kent State University, USA |
| Santosh D'Mello, PhD | Neugeneron, USA |
| Terrence Deak, PhD | Binghamton University, USA |
| Alvaro Estevez, PhD | Oregon State University, USA |
| Max L. Fletcher, II, PhD | University of Tennessee Health Science Center, USA |
| James Hewett, PhD | Syracuse University, USA |
| Sandra J. Hewett, PhD | Syracuse University, USA |
| Sandra Mooney, PhD | University of North Carolina, USA |
| Gregg D. Stanwood, PhD | Florida State University, USA |
| Mingqing Xu, PhD | Shanghai Jiao Tong University, China |
| Y. James Kang, DVM, PhD | Sichuan University West China Hospital, China |
| Matthias Barton, MD | University of Zurich, Switzerland |
| Guzel Bikbova, MD/PhD | Chiba Univesrity, Japan |
| Pawel Brzuzan, PhD | University of Warmia and Mazury in Olsztyn, Poland |
| Laetitia Dou, PhD | Aix-Marseille Universite, France |
| Samuel Gnana Prakash Vincent, PhD | Manonmaniam Sundaranar University, India |
| Youngmi Jung, PhD | Pusan National University, Korea |
| Li-Fu Li, MD/PhD | Chang Gung Memorial Hospital and Chang Gung University, Taiwan |
| Jonathan Henry Shannahan, PhD | Purdue University, USA |
| Martin Sterba, PhD | Charles University Faculty of Medicine in Hradec Kralove,Czech Republic |
| Chaowu Xiao, PhD | Health Canada, Canada |
| Wuxiang Xie, PhD | Imperial College London, UK |
| Qihe Xu, MD/PhD | Kings College London, UK |
| Robert T. Mallet, PhD | University of North Texas, USA |
| R. Todd Alexander, MD/PhD | University of Alberta, Canada |
| Frantisek Kolar, PhD | Academy of Sciences of the Czech Republic, Czech Republic |
| Rong Ma, MD/PhD | University of North Texas Health Science Center, USA |
| Jiri Pacha, PhD | Academy of Sciences of Czech Republic, Czech Republic |
| Gabor Joseph Tigyi, M.D., Ph.D | University of Tennessee Health Science Center, USA |
| Shaw-Jeng Tsai, PhD | National Cheng-Kung University Medical College, Taiwan |
| Samuel Verges, PhD | Grenoble Alps University, France |
| Tobias Wang, PhD | Aarhus University, Denmark |
| Lei Xi, MD | Virginia Commonwealth University, USA |
| Shaohua Yang, MD, PhD | University of North Texas Health Science Center, USA |
| Chunyu Zeng, MD | The Third Military Medical University, Chongqing City, China |
| Jian Feng, PhD | State University of New York at Buffalo, USA |
| Vania Broccoli, PhD | San Raffaele Scientific Institute, Milano, Italy |
| Jose Cibelli, DVM | Michigan State University, USA |
| Guoping Fan, PhD | University of California, Los Angeles, USA |
| Meri T. Firpo, PhD | Memphis Meats, USA |
| Antonis Hatzopoulos, PhD | Vanderbilt University, USA |
| Yoon-Young Jang, MD, PhD | Johns Hopkins University School of Medicine, USA |
| Dan S. Kaufman, MD | University of California, San Diego, USA |
| Mark Mercola, PhD | Stanford University, USA |
| Steven Stice, PhD | University of Georgia, USA |
| Chun-Li Zhang, PhD | UT Southwestern Medical Center, USA |
| Thomas B. Thompson, PhD | University of Cincinnati College of Medicine, USA |
| Andrew P. Hinck, PhD | University of Pittsburgh, USA |
| James R. Horn, PhD | Northern Illinois University, USA |
| Douglas John Kojetin, PhD | Scripps Florida, USA |
| Rhett A. Kovall, PhD | University of Cincinnati College of Medicine, USA |
| Vincent C. Luca, PhD | Moffitt Cancer Center & Research Institute, USA |
| Rick Page, PhD | Miami University, USA |
| Ana Carolina M. Zeri, PhD | Brazilian Biosciences National Laboratory, Brazil |
| Tara L. Deans, PhD | University of Utah, USA |
| Jenny C. Mortimer | Lawrence Berkeley National Laboratory, USA |
| Andre Levchenko, PhD | Yale Systems Biology Institute, USA |
| Rashid Bashir, PhD | University of Illinois, Urbana-Champaign, USA |
| Richard A. Gray, PhD | Food and Drug Administration, USA |
| Salman K. Khetani, PhD | University of Illinois at Chicago, USA |
| Philip R. LeDuc, MD | Carnegie Melon University, USA |
| Peter Loskill, PhD | Fraunhofer Institute, Germany |
| D. Lansing Taylor, PhD | University of Pittsburgh, USA |
| Betty S. Pace, MD | Augusta University, USA |
| Jing An, MD, PhD | University of California San Diego, USA |
| Roy Baynes, PhD | Merck Inc., USA |
| Yukai He, MD, PhD | Augusta University, USA |
| Hyacinth I. Hyacinth, MD, PhD, MPH | University of Cincinnati, USA |
| Chulso Moon, MD, PhD | HJM Research Foundation, USA |
| Esther A. Obeng, MD, PhD | St. Jude Children’s Research Hospital, USA |
| Jeffrey Schlom, PhD | National Cancer Institute, USA |
| Vivien Sheehan, MD/PhD | Emory University School of Medicine, USA |
Please read the Instructions to Authors below before visiting the Journal’s submission site (https://mc.manuscriptcentral.com/ebm) to submit your manuscript. Please note that manuscripts not conforming to these guidelines will be returned for modification. These instructions comply with the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals formulated by the International Committee of Medical Journal Editors (ICMJE). Any correspondence, queries or requests for additional information should be sent to the Experimental Biology and Medicine Editorial Office (ebm@sebm.org).
1.1 Aims & Scope
1.2 Article types
2.2 Authorship
2.3 Acknowledgements
2.6 Research ethics
2.7 Dual Submission
2.8 Preprints
3.1 Plagiarism
3.2 Contributor's publishing agreement
3.3 Open access and author archiving
4.1 Cover Letter
4.2 Main Document
4.3 Tables
4.4 Figures
4.5 Statistics
4.8 Conflict of Interest Disclosure Form
4.9 English language editing services
4.10 Revised manuscripts
5.1 User Accounts
5.2 Information required for completing your submission
5.3 Manuscript PDF
5.4 ORCID
5.5 Permissions
7. Publication
7.1 SAGE Production
7.3 Access to your published article
Experimental Biology and Medicine is particularly appropriate for publication of papers that are multidisciplinary in nature, are of potential interest to a wide audience, and represent experimental medicine in the broadest sense of the term. However, manuscripts reporting novel findings on any topic in the realm of experimental biology and medicine are most welcome. We particularly encourage submission of manuscripts that describe results of studies that require an interdisciplinary approach to biomedical issues.
Categories currently listed in EBM are: Anatomy/Pathology; Biochemistry and Molecular Biology; Bioimaging; Biomedical Engineering; Bionanoscience; Cell and Developmental Biology; Clinical Trials; Endocrinology and Nutrition; Environmental Health/Biomarkers/Precision Medicine; Genomics, Proteomics, and Bioinformatics; Immunology/Microbiology/Virology; Mechanisms of Aging; Neuroscience; Pharmacology and Toxicology; Physiology; Stem Cell Biology; Structural Biology; Synthetic Biology; Systems Biology and Microphysiological Systems; and Translational Research. For more information on these topics please click here to review the category descriptions. Authors should indicate their preference of category in the on-line submission form, although the final decision of reviewing Associate Editor and section Editorial Board rests with the Editor-in-Chief.
Original Research: Manuscripts describing complete studies that are of high impact to the field will be published as Original Research. Manuscripts should be as concise as possible, yet sufficiently detailed to permit critical appraisal, and should generally not exceed 40 typed pages (including tables, figures and references). Unnecessary subdivision of a study into several manuscripts is not acceptable. Formatting should follow the requirements in Section 4: Manuscript Preparation.
Brief Communications: Manuscripts describing focused studies that are concise and of high impact to a field will be published as Brief Communications. This format is intended for the presentation of scientifically sound and novel research in a clear and concise fashion. The body of the paper should not exceed nine (9) pages of double-spaced text with references. Tables and Figures must also be kept to a minimum (no more than four). The Results and Discussion sections can be presented individually or combined into a single section. Otherwise, formatting should follow the requirements in Section 4: Manuscript Preparation.
Minireviews: The journal publishes review articles under the section heading "Minireviews." Although there is no page limit, the reviews are generally short (~20 pages of double-spaced text with references). They should reflect the state-of-the-art of the area being reviewed and often include a brief history of the field. There is no need to include an exhaustive literature survey. Emphasis upon a particular hypothesis or point of view or upon the personal opinions or interpretation of the writer or upon the work of the writer's laboratory is appropriate, provided that this focus is clearly indicated in the paper. Most reviews are submitted in response to an invitation from the Editor-in-Chief and are subjected to the usual review process prior to publication. Unsolicited reviews require approval by the Editor-in-Chief before receiving peer review. Minireviews should not include Materials and Methods or Results sections. Otherwise, formatting should follow the requirements in Section 4: Manuscript Preparation.
Comments: The Journal, at the Editor-in-Chief's discretion, will publish, under the section heading "Comments", letters or essays from readers discussing articles that have recently appeared in the Journal or other timely topics of interest to the Journal's readership. The author of a letter or essay which is published accepts full responsibility for the contents of the letter. Letters discussing a published article may for example include supporting information, clarifications, criticisms, corrections, alternate interpretations or perspectives. Such letters will be sent to the corresponding author of that article prior to publication. If the corresponding or other author wishes, her/his response will be published together with the original letter. At the discretion of the editor, essays or letters discussing controversial issues may be sent to persons representing alternative viewpoints who will be encouraged to provide responses. If the Editor decides to publish such responses, they will be sent to the original author for comments prior to publication. In some cases, the Editor-in-Chief may send a letter or essay for outside review prior to deciding whether to publish it. The Journal reserves the right to edit these communications without materially changing their meaning.
Only manuscripts of sufficient quality that meet the aims and scope of Experimental Biology and Medicine will be processed for review. Manuscripts are assigned to Global Editors based on the country of origin. Manuscripts from countries without Global Editors are assigned to the Editor-in-Chief. Impactful manuscripts deemed by the Global Editor to fall within the interests of the Journal's readership and to be written in clear, concise and grammatical English are assigned to an Associate Editor.
Manuscripts are assigned to Associate Editors based on subject category (see section 1.1). Authors should indicate their preference of category during the submission process. However, the final decision of reviewing Associate Editor and section Editorial Board rests with the Editor-in-Chief. If the reviewing Associate Editor determines that the manuscript has sufficient impact and scientific rigor, and the English language is suitable for review, then he/she will assign reviewers.
Generally, two reviewers will evaluate each manuscript on the basis of scientific rigor of the experimental design, adequacy of the data, validity of the conclusions, importance and originality of the studies, adequacy of the literature citations, clarity of the presentation, and interest to the Journal's readership. Manuscripts will be given a quality (priority) ranking by each reviewer. Those manuscripts with low priority rankings will not be accepted even though they may have been classed as generally acceptable. If reviewers differ significantly in their opinions, decision will be based on the priority rankings and/or the opinion of an additional reviewer (arbiter). Normally, revised manuscripts are sent back to the original reviewers together with the authors' responses.
The reviewers' comments will be held in confidence except as follows: (a) the reviewers' comments may be sent, in whole or in part, to the corresponding author; (b) after revision, each reviewer's comments will be sent, in whole or in part, to the other reviewers of the manuscript: and (c) in the event that there is a significant difference in opinion between or among the reviewers, the manuscript may be sent to an additional reviewer (arbiter) together with the comments, in whole or in part, of the other reviewers. In all cases, anonymity of the reviewers will be maintained.
Papers should only be submitted for consideration once consent is given by all contributing authors. Those submitting papers should carefully check that all those whose work contributed to the paper are acknowledged as contributing authors.
The list of authors should include all those who can legitimately claim authorship. This is all those who:
- Made a substantial contribution to the concept or design of the work; or acquisition, analysis or interpretation of data,
- Drafted the article or revised it critically for important intellectual content,
- Approved the version to be published,
- Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content.
Authors should meet the conditions of all of the points above. When a large, multicentre group has conducted the work, the group should identify the individuals who accept direct responsibility for the manuscript. These individuals should fully meet the criteria for authorship.
Acquisition of funding, collection of data, or general supervision of the research group alone does not constitute authorship. All contributors who do not meet the criteria for authorship should be listed in the Acknowledgments section. Please refer to the International Committee of Medical Journal Editors (ICMJE) authorship guidelines for more information on authorship (http://www.icmje.org/recommendations/browse/roles-and-responsibilities/d...).
All contributors who do not meet the criteria for authorship should be listed in an Acknowledgements section. Examples of those who might be acknowledged include a person who provided purely technical help, or a department chair who provided only general support.
Experimental Biology and Medicine requires that all authors acknowledge all grant, contract and industrial support of the work in the published article and on-line submission form. All submitted articles must include a Funding section/statement in the Main Document (see section 4.2).
Authors are required at the time of submission to disclose potential conflict of interests (eg., consultancies, stock ownership, equity interests, patent-licensing arrangements, lack of access to data, or lack of control of the decision to publish) in the on-line submission form. A YES answer to the Conflict of Interest question requires that additional details be provided in the on-line form and that a Conflict of Interest Disclosure form(s) be submitted (see section 4.8). Such information, unless already disclosed in the submitted manuscript, will be held in confidence while the paper is under review. If the manuscript is accepted for publication, any information on the potential conflict of interest not disclosed in the submitted article, including a lack of control of the decision to publish, will be inserted during typesetting. The corresponding author is responsible for obtaining signed forms from all authors that have a potential conflict of interest (see section 4.8).
For guidance on conflict of interest statements, please see the ICMJE recommendations (http://www.icmje.org/recommendations/browse/roles-and-responsibilities/a...). Guidelines for formatting the Declaration of Conflicting Interests section/statement in the Main Document can be found in section 4.2..
Studies involving human subjects must conform to the ethical standards set by the Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research; must have been reviewed and approved by the appropriate institutional Review Board (IRB); and must be presented in such a manner as to assure preservation of the anonymity of the subjects. It must be stated in the Materials and Methods section of the article that the study had been approved by the responsible IRB and that informed consent was obtained from research subjects or it must be explained why IRB review and /or informed consent were not required. Please ensure that you have provided the full name and institution of the review committee, in addition to the approval number in the Ethical Approval section/statement in the Main Document (see section 4.2).
It is the Journal's policy that all studies involving the use of animals be conducted in compliance with applicable laws and regulations as well as the principles expressed in the National Institutes of Health, USPHS, Guide for the Care and Use of Laboratory Animals, and that the studies be conducted on animals that were lawfully acquired. Use of animals must have been approved by the Institution's Animal Care and Use Committee (IACUC) and this must be stated in the Materials and Methods section of the article. If the study was conducted in a jurisdiction where such review is not required, this should be noted in the Materials and Methods section.
Experiments involving recombinant DNA must have been reviewed and approved as required by applicable laws and regulations.
Manuscripts are accepted for review with the understanding that the same work has not been submitted or published elsewhere and, if accepted by the Journal, will not be submitted or published elsewhere. If evidence of dual submission is found, the manuscript will be rejected or, if published, retracted. Posting submitted material on a web site prior to publication may also be considered dual submission. If any material published previously is included, for clarity or other reasons, this should be indicated with appropriate citation in the manuscript. Contact the Editorial office at ebm@sebm.org if you require further information.
Experimental Biology and Medicine will accept submissions posted on non-profit preprint servers only if they are posted prior to submission on bioRxiv (https://www.biorxiv.org) or medRxiv (https://www.medrxiv.org). Preprints are defined as an author’s version of a research manuscript prior to formal peer review at a journal, which is deposited on a public server (as described in Preprints for the life sciences. Science 352, 899–901; 2016). Posting on any preprint server after submission, or a non-approved pre-print server prior to submission will be considered dual submission. If evidence of dual submission is found, the manuscript will be rejected or, if published, retracted.
Authors must provide the DOI for the preprint during the on-line submission process (Step 6: Details and Comments). If the paper is accepted by EBM, the author agrees to ask the preprint archive to include a link to the published article and its DOI.
As for all articles, the editors consider novelty when making manuscript decisions, and publication priority can be affected if significant publicity occurs before or during the peer-review process.
The knowing duplication of published work without appropriate attribution will not be tolerated. This policy covers all material, whether in the form of text, tables, figures or other exhibits, which has been published or is being considered for publication in another journal, and applies to the published work of the submitting author(s) as well as the work of other investigators.
Experimental Biology and Medicine and SAGE take issues of copyright infringement, plagiarism or other breaches of best practice in publication very seriously. We seek to protect the rights of our authors and we always investigate claims of plagiarism or misuse of published articles. Equally, we seek to protect the reputation of the journal against malpractice. Submitted articles may be checked with duplication-checking software. Where an article, for example, is found to have plagiarised other work or included third-party copyright material without permission or with insufficient acknowledgement, or where the authorship of the article is contested, we reserve the right to take action including, but not limited to: publishing an erratum or corrigendum (correction); retracting the article; taking up the matter with the head of department or dean of the author's institution and/or relevant academic bodies or societies; or taking appropriate legal action.
Three levels of plagiarism are covered by this policy, with progressively more severe sanctions: Level one: Limited duplication of text from the authors' own published work, with somewhat more relaxed stringency for materials and methods: In these cases, the manuscript will be returned to the authors with instructions to rewrite/rephrase the duplicated text, before publication of the submission may proceed. If the materials and methods are heavily duplicated, the authors could be advised to reference their published work, thereby shortening that section. Level two: Substantial duplication of an author's own work, or significant duplication of the work of others, will result in rejection of the manuscript or retraction after publication. Level three: Duplication of an author's own work so extensive that it could be considered an attempt to publish the same work twice (dual or redundant publication), or lifting of large chunks of text or data from the work of others, will result in rejection of the manuscript or retraction after publication and, in addition, contacting the appropriate officials at the author's institution.
Submitted manuscripts which, following the initial review, have a likelihood of eventual publication in EBM, will be evaluated by advanced plagiarism detection software, which systematically compares the manuscript against an extensive database of published literature and websites. If the software identifies possible plagiarism, further investigation will be conducted by the Associate Editor of the assigned section of EBM. Findings of potential plagiarism requiring one of the sanctions described above will be forwarded to the Editor-in-Chief for further review. Every effort will be made to conduct these reviews in a careful, fair and impartial manner, to avoid inappropriate imposition of sanctions. EBM urges submitting authors to avoid duplication either of their own work or that of others, and recommends authors evaluate their manuscripts with plagiarism-detecting software before submitting their work to EBM.
3.2 Contributor's publishing agreement
Before publication, SAGE requires the author as the rights holder to sign a Journal Contributor’s Publishing Agreement. Authors of accepted manuscripts will be required to assign copyright to the Society for Experimental Biology and Medicine (SEBM). For more information please visit the SAGE Author Gateway (https://uk.sagepub.com/en-gb/eur/contributor-agreement).
3.3 Open access and author archiving
Experimental Biology and Medicine offers optional open access publishing via the SAGE Choice programme. For more information please visit the SAGE Choice website (https://uk.sagepub.com/en-gb/eur/sage-choice). For information on funding body compliance, and depositing your article in repositories, please visit SAGE Publishing Policies (https://uk.sagepub.com/en-gb/eur/copyright-and-permissions).
The cover letter is important as it helps the Editor in his/her preliminary evaluation. The letter should indicate why you think the paper is suitable for publication; how your paper is innovative, provocative, timely, and of interest to a broad audience. The letter should list any paper on related topics by any of the authors that have been published within the past year or that are in review or in press. The letter must state that the non-signing author(s) have read and approved the manuscript. The cover letter can be copied/pasted or attached as a file in the Cover Letter section of the on-line submission form (Step 6: Details and Comments).
The Main Document must be a word file formatted using 1 inch margins, 11 pt or larger font size, double-spacing, unjustified text, and single-column text. Do not use numbers/letters in headings or subheadings.
Trade name, popular name or abbreviation when first used must be preceded by the chemical, scientific or technical name. Trade names should begin with a capital letter. Structural formulas of chemicals should be used only when absolutely necessary. Symbols and abbreviations should be those currently in use. Authors should not create new abbreviations and acronyms. Lists of abbreviations are not permitted. All measurements should be expressed in SI units.
For original research and brief communication articles the Main Document file should include the following sections, in the following order: Title Page, Abstract/Keywords, Impact Statement, Introduction, Materials and Methods, Results, Discussion, Authors’ Contributions, Acknowledgements (if applicable), Declaration of Conflicting Interests, Ethical Approval (if applicable, see section 2.6), Funding, Figure Legends and References. In brief communications, the Results and Discussion sections can be combined.
Minireviews should also contain the following sections: Title Page, Abstract/Keywords, Impact Statement, Introduction, main text, Authors’ Contributions, Acknowledgements (if applicable), Declaration of Conflicting Interests, Funding, Figure Legends and References.
Title page: The Title page should be the first page of the Main Document and include the following information: full title of the manuscript, a short running title, the author(s) name(s), the author(s) affiliation(s) (including postal/zip codes) and corresponding author information (name, postal address and email address).
The title should be a declarative statement of key findings and should be limited to 15 words. Use of abbreviations in the title should generally be avoided.
Do not include degrees in the list of authors.
The title and author names/order on the Title page must exactly match those in the on-line submission form.
Abstract: An abstract of no more than 300 words should be placed on the page following the Title page and formatted as a single paragraph. Structured abstracts with subheadings are not permitted. The abstract should be copied/pasted in Abstract section of the on-line form (Section 1: Type, Title and Abstract).
Impact Statement: An Impact Statement is required for all submissions. Your impact statement will be evaluated by the Editor-in-Chief, Global Editors, and appropriate Associate Editor. They must be convinced that the manuscript is an important advance in your field for your manuscript to receive full review. The Impact Statement is not a restating of the abstract. It should address the following:
- Why is the work submitted important to the field?
- How does the work submitted advance the field?
- What new information does this work impart to the field?
- How does this new information impact the field?
The Impact statement should be no more than 150 words and formatted as a single paragraph without questions. Lists are not permitted. The Impact Statement will be included as a boxed statement on the first page of the article, separate from the Abstract. The Impact statement should be copied/pasted in the Impact Statement section of the on-line form (Section 1: Type, Title and Abstract).
Authors’ Contributions: Authors must include a statement that specifies the actual contribution of each co-author to the completed work. The “Authors’ Contributions” statement should be placed immediately after the Discussion/Conclusions and formatted as a single paragraph. For example: "All authors participated in the design, interpretation of the studies and analysis of the data and review of the manuscript; MPV, MNS, KAM, and YZ conducted the experiments, RJS supplied critical reagents [or animals] (specify), RAS and WEZ wrote the manuscript, and XYZ contributed [other] (specify)."
Acknowledgments: Individuals whose contribution does not reach the level required for their inclusion as an author should be acknowledged in the traditional way, with their full names(s) given. For example, "The authors thank Dr. John Doe for advice in statistical analysis".
The corresponding author must verify that all individuals who made contributions to this study are included either as authors or are acknowledged at the end of the paper.
Declaration of Conflicting Interests: Authors are required at the time of submission to disclose potential conflict of interests (eg., consultancies, stock ownership, equity interests, patent-licensing arrangements, lack of access to data, or lack of control of the decision to publish) in the on-line submission form (see section 2.5). If no conflict exists, please state that “The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article”.
Ethical Approval (if applicable): For studies involving human subjects, provide the full name and institution of the review committee (see Section 2.6 Research Ethics).
Funding: The funding agency should be written out in full, followed by the grant number in square brackets, see following example: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Medical Research Council [grant number xxx].
Multiple grant numbers should be separated by comma and space. Where the research was supported by more than one agency, the different agencies should be separated by semi-colon, with “and” before the final funder. For example: This work was supported by the Trust [grant numbers xxxx, yyyy]; the Natural Environment Research Council [grant number zzzz]; and the Economic and Social Research Council [grant number aaaa].
Where no specific funding has been provided for the research authors should state that: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Figure Legends: Legends for figures should be placed before the References in the Main Document. Legends for supplementary figures should be included in the supplementary files and NOT in the Main Document. Legends should contain sufficient experimental detail to permit the figures to be interpreted without reference to the text.
References: Extensive citation should be avoided, if possible, while adhering to the applicable conventions of the scientific community. Authors are responsible for verifying citations against the original source material, and for obtaining permission to reproduce from the appropriate sources cited in the text. Citation of non-peer-reviewed publications is not permitted. "Personal communication", "unpublished", "submitted" and references with DOIs only must be excluded from the references.
References should be arranged numerically at the end of the manuscript, cited in the text with superscript numerals, and numbered consecutively in order of their citation in the text (ENDNOTE template Experimental Biology and Medicine (Maywood)). Examples are shown below:
Zhang X, Wang J, Fan Y, Yang L, Wang L, Ma J. Zinc supplementation attenuates high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelial cells. Biol Trace Elem Res 2012;150:229–35
Weatherall D, Clegg J. The molecular pathology of the thalassaemias. The Thalassaemia Syndromes, 4th ed. Oxford: Wiley-Blackwell, 2001, pp. 133–91
Tables should not duplicate information given in the text, numbered with Arabic numerals and cited consecutively in the text. Each table should be titled and double-spaced on a separate page. The title of each table should clearly indicate the nature of the contents, and sufficient experimental detail should be included in footnotes in the table to permit the reader to interpret the results without reference to the text. Units must be clearly indicated for each of the entries in the table.
Tables should be submitted as individual word files (1 table/file), with all columns contained on a single page. Tables should be uploaded/submitted in sequential order immediately following the Main Document. Filenames should use the following template: Table X, where X is table number.
All figures should be cited consecutively by Arabic numerals in the text. Figures should be submitted as individual word, jpeg, tiff or ppt files (1 figure/file) in such form as to permit photographic reproduction without retouching or redrawing. Units should be clearly indicated in the figures themselves. The lettering should be large enough to allow a reduction of two thirds. In addition, all text must be legible at 100% (i.e. without zooming/enlargement) in the PDF generated for reviewers and editors.
Figures should be uploaded/submitted in sequential order immediately following the Tables, or Main Document if there are no tables. Filenames should use the following template: Figure X, where X is figure number.
Figures supplied in color will appear in color online regardless of whether or not these illustrations are reproduced in color in the printed version. Information regarding color reproduction in print, will be provided after manuscripts are accepted (see Section 6 Publication Charges).
Guidelines to assist authors prepare statistical data for publication can be found in the EBM Statistical Guidelines.These guidelines are not a substitute for the detailed guidance required to design a study or perform a statistical analysis.
Supplementary material relevant to scientific review should be uploaded/submitted as a Supplementary for Review file. Supplementary for Review files are available to reviewers/editors. If a manuscript is accepted, these files are available for download on-line as provided without modification or typesetting by the publisher. Authors are strongly encouraged to submit all supplementary material for review in a single PDF file after the figure files. Multiple files may be uploaded/submitted if warranted.
Supplementary material that is not essential for scientific review should be uploaded/submitted as a Supplementary Not for Review file. These files are available to editors and administrative staff only; they are not available to reviewers or readers. The Mandatory Submission form (required), Copyediting Certificate (if applicable), and Conflict of Interest Disclosure form (if applicable) should be uploaded/submitted as Supplementary Not for Review files and be the final manuscript files. Filenames should include the name of the form.
A completed Mandatory Submission Form is required for all submissions. Authors should sign in English in the same order as on the manuscript title page. Computer generated signatures are NOT accepted. Multiple pages are acceptable, but all pages should be uploaded/submitted in a single Supplementary Not for Review file at the end of the manuscript files.
4.8 Conflict of Interest Disclosure Form
A YES answer to the Conflict of Interest question in the on-line form requires the submission of completed Conflict of Interest Disclosure Form(s) (see section 2.5). All pages/forms should be uploaded/submitted in a single Supplementary Not for Review file after the Mandatory Submission form.
4.9 English language editing services
If English is not your native language, you may find it helpful to obtain assistance in writing your papers before submission. This may not only save time in the review process but also increase the effectiveness of your submission. Quality of written English is judged by the Editor-in-Chief, Global Editors, and appropriate Associate Editor. They must be convinced that the quality of written English is sufficient for your manuscript to receive full review. EBM offers low-cost English services for authors (http://www.EBMEnglishServices.squarespace.com)
A YES answer to the copyediting question in the on-line submission form requires that a copy of the editing certificate be submitted as a Supplementary Not for Review file after the Mandatory Submission form, or Conflict of Interest form (if applicable).
When, as a result of reviewers' comments, it is necessary to revise a manuscript, it is recommended that authors submit the revised manuscript within the time-frame allotted in the decision letter. Longer delays may result in the revised manuscript receiving a lower priority score. Extensions require approval by the Associate Editor and should be requested prior to the due date as the on-line submission system will not permit submission if the revision option has expired. Journal policy permits only ONE extension. Delays in excess of 60 days require submission as a new manuscript.
Revised submission must include a detailed response to the decision letter for the previous version. The response letter should be uploaded/submitted during the on-line submission process (Step 1: View and Respond to Decision Letter). Do not include the response letter in the manuscript files. In addition, modifications in the manuscript files must be denoted using red text. Do not use highlights to denote modified text.
Experimental Biology and Medicine is hosted on SAGE Track, a web based online submission and peer review system powered by ScholarOne™ Manuscripts (https://mc.manuscriptcentral.com/ebm). For further guidance on submitting your manuscript online please visit http://mchelp.manuscriptcentral.com/gethelpnow/.
Before creating a new user account, please verify that you do not already have an account in the system. If you have reviewed or authored for the Journal in the past, it is likely that you will have an account in the system.
5.2 Information required for completing your submission
As part of the submission process you will be required to state that you are submitting your original work, that you have the rights in the work, that you are submitting the work for first publication in the Journal, that it is not being considered for publication elsewhere, that it has not already been published elsewhere, and that you have obtained and can supply all necessary permissions for the reproduction of any copyright works not owned by you.
You will be asked to provide valid email addresses, contact details, and academic affiliations for all co-authors and identify who is to be the corresponding author. You will also be asked to provide an Abstract, keywords, an Impact statement, Funding information, and Conflict of Interest information. These details must match what appears in the Main Document file. You will also be asked to select a section/category and provide information regarding copyediting and membership in the Society for Experimental Biology and Medicine. You can, but are not required to, provide information regarding recommended and/or opposed reviewers. Finally, you will be asked to verify that your submission meets all guidelines outlined in these Instructions.
The submission system will generate a PDF for reviewers. Please review this file carefully and ensure your submission documents have been properly converted, as this is the ONLY file provided to reviewers.
As part of our commitment to ensuring an ethical, transparent and fair peer review process SAGE is a supporting member of ORCID, the Open Researcher and Contributor ID. ORCID provides a unique and persistent digital identifier that distinguishes researchers from every other researcher, even those who share the same name, and, through integration in key research workflows such as manuscript and grant submission, supports automated linkages between researchers and their professional activities, ensuring that their work is recognized.
The collection of ORCID iDs from corresponding authors is now part of the submission process of this journal. If you already have an ORCID iD you will be asked to associate that to your submission during the online submission process. We also strongly encourage all co-authors to link their ORCID ID to their accounts in our online peer review platforms. It takes seconds to do: click the link when prompted, sign into your ORCID account and our systems are automatically updated. Your ORCID iD will become part of your accepted publication’s metadata, making your work attributable to you and only you. Your ORCID iD is published with your article so that fellow researchers reading your work can link to your ORCID profile and from there link to your other publications.
If you do not already have an ORCID iD please visit https://orcid.org.
Please also ensure that you have obtained any necessary permission from copyright holders for reproducing any illustrations, tables, figures or lengthy quotations previously published elsewhere. For further information including guidance on fair dealing for criticism and review, please see the Copyright and Permissions page on the SAGE Author Gateway (https://uk.sagepub.com/en-gb/eur/copyright-and-permissions).
Authors are required to pay a part of the cost of publication in the form of a page charge of $70 per typeset page. There are no page charges for articles where the first or corresponding author is an SEBM member in good standing at the time of manuscript submission.
There are no charges for color figures that are reproduced in color on-line and B&W in print. If authors choose to have color figures reproduced in color print, there is a charge of $700 for each color page. There is a discounted color page rate for articles where the first or corresponding author is an SEBM member in good standing at the time of manuscript submission
Authors lacking funding from grant or other sources may apply at the time of submission for a waiver of page charges. Apply for a waiver of page charges on institutional letterhead at the time of submission. The request must be sent via email (ebm@sebm.org) and include a letter endorsed by a senior institutional official verifying that no funds are available for paying page charges. A waiver of page charges will not be granted once an initial decision has been rendered on the manuscript. Once a waiver has been approved and a paper published authors may not request a waiver for any future manuscripts.
Your SAGE Production Editor will keep you informed as to your article’s progress throughout the production process. Proofs will be sent by PDF to the corresponding author and should be returned promptly. Corrections should be kept to a minimum. Authors will be charged for excessive changes. Authors are reminded to check their proofs carefully to confirm that all author information, including names, affiliations, sequence and contact details are correct, and that Funding and Conflict of Interest statements, if any, are accurate.
Online First allows final articles (completed and approved articles awaiting assignment to a future issue) to be published online prior to their inclusion in a journal issue, which significantly reduces the lead time between submission and publication.
7.3 Access to your published article
SAGE provides authors with online access to their final article. A link is provided allowing the author to download the article directly from the SAGE website and forward the link onto their co-authors.
Publication is not the end of the process! You can help disseminate your paper and ensure it is as widely read and cited as possible. The SAGE Author Gateway has numerous resources to help you promote your work (https://uk.sagepub.com/en-gb/eur/promote-your-article). In addition, SAGE is partnered with Kudos, a free service that allows authors to explain, enrich, share, and measure the impact of their article (https://uk.sagepub.com/en-gb/eur/maximize-your-articles-impact-with-kudos)