You are here

Resources to help you transition to teaching online

Instructors: To support your transition to online learning, please see our resources and tools page whether you are teaching in the UK, or teaching outside of the UK.

Inspection copy update April 2020: Due to the current restrictions in place in response to COVID-19, our inspection copy policy has changed. Please refer to our updated inspection copy policy for full details. If you have recently placed an inspection copy order with us, we will be in touch to advise of any changes.

ICRP Publication 83
Share

ICRP Publication 83
Risk Estimation for Multifactorial Diseases


Other Titles in:
Public Health | Radiology

December 2000 | 136 pages | SAGE Publications Ltd
ICRP Publication 83 reviews data on naturally occurring multifactorial diseases and develops a mathematical model to predict the impact of radiation induced mutations on the frequencies of these diseases in the population. It provides a broad outline of the aetiological features and examples of multifactorial diseases. It considers the concepts and models used to explain their inheritance patterns, with particular emphasis on the Multifactorial Threshold Model. Conceptual differences from ‘mendelian’ diseases are discussed, and pertinent epidemiology is reviewed. Particular attention is paid to diabetes mellitus and to coronary heart disease. Mechanistic models in population genetics are considered. The concepts of liability, threshold, mutation-selection balance, and mutation component are integrated into a Finite Locus Threshold Model as a basis for risk estimation. The relevance of these findings for estimation of radiation risk of multifactorial diseases is discussed.

Preview this book

Select a Purchasing Option

ISBN: 9780080439006
£157.00